5 Genetic Factors That Increase Your Risk of Lower Back Pain

Have you ever wondered why some people seem more prone to lower back pain than others, despite leading similar lifestyles? While factors such as posture, physical activity, and diet certainly play a role, research suggests that genetics may contribute to your risk of developing lower back pain.

Understanding the genetic basis of lower back pain Las Vegas can not only shed light on the underlying causes of this condition. However, it may also open new avenues for personalized treatment and prevention strategies. This article will explore five genetic factors that may increase your risk of developing lower back pain as you age.  

Inherited Structural Abnormalities

Inherited structural abnormalities are one of the genetic factors that can increase your risk of lower back pain. These abnormalities are present at birth and affect your spine’s structure, making it more susceptible to damage and injury over time. 

Common structural abnormalities include scoliosis and spinal stenosis. These conditions often pressure the spinal nerves leading to lower back pain. While not all individuals with these structural abnormalities will develop lower back pain, they increase the risk. Always monitor your symptoms and seek treatment when necessary. 

Disc Degeneration

Studies suggest that certain genetic variations can increase your risk of developing intervertebral disc degeneration, leading to lower back pain. One example is the COL9A2 gene, which plays a role in the structure and function of intervertebral discs. Variations in this gene are associated with an increased risk of disc degeneration and lower back pain.

Other genes, such as those involved in inflammation and oxidative stress, may also contribute to disc degeneration and lower back pain. If you are at a higher risk of disc degeneration, take the necessary steps, such as maintaining proper posture to prevent and manage your condition. 

Collagen Disorders

Genetic disorders that affect collagen, a protein that provides structure and support to your body’s connective tissues, can increase your risk of developing lower back pain. These disorders can lead to weakened or abnormal connective tissues in the spine, causing the discs and ligaments to be more prone to injury and degeneration. 

This effect can lead to chronic or intermittent lower back pain. In addition, these collagen disorders can also affect other parts of the body, such as the joints and skin, and lead to additional pain and discomfort.

Inflammatory Conditions

Genetic variations may increase the risk of developing inflammatory conditions, such as ankylosing spondylitis or rheumatoid arthritis, which can cause lower back pain. Ankylosing spondylitis primarily affects the spine and sacroiliac joints, causing pain and stiffness in the lower back. 

Research suggests that certain genes, such as the HLA-B27 gene variant, may play a role in developing ankylosing spondylitis. Similarly, rheumatoid arthritis is considered a major risk factor for lower back pain, with several genes implicated in developing the disease, including the HLA-DRB1 gene.

Pain Sensitivity

Some studies have suggested that genetic factors can influence your pain sensitivity, affecting your likelihood of experiencing lower back pain. People with certain genetic variants may be more or less sensitive to pain. These genetic variants can affect how they respond to lower back pain triggers such as prolonged sitting, standing, or lifting heavy objects. 

Moreover, genetics may also influence your response to pain medications. For example, certain genetic variations in the CYP2D6 gene can affect how your body metabolizes opioid painkillers, affecting their effectiveness and risk of side effects.

While genetics cannot be changed, lifestyle modifications such as maintaining good posture, regular exercise, and a healthy diet can help reduce the risk of lower back pain. Furthermore, early intervention and appropriate treatment can help manage the symptoms of lower back pain and prevent it from becoming a chronic condition. 

Understanding the above genetic factors and taking appropriate measures can reduce your risk of lower back pain and help you live a healthy, pain-free life. Also, remember to track your symptoms, as this information can help your doctor determine the rate of your pain progression and provide the best form of treatment.

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Chiara Brunner